The In Vivo Imaging Core Facility offers services seamed to integrate cellular work, animal models, fluorescent imaging systems, radiochemistry and hybrid radioisotope imaging of live animal biodistribution and protein functions. Our services are truly scientific in nature which means we have formed our activities flexible to satisfy the demanding but ever changing discovery tasks for our Partners. In offering scientific flexibility, we implement regular, producer-prescribed quality control standard operational procedures for our measurement systems from pipettes to imaging devices. We also perform quantification and linearity tests together with our Partners on SPECT, PET and CT systems at the beginning of each project.
In Vivo Imaging measures protein concentrations, enzyme, transporter and ion channel functions in intact animals. Our isotope-labeled studies can measure receptor dissociation constants and total body biodistribution of different drug molecules. We have a unique expertise in nanoparticle and cell tracking. All these are obtained using the world’s most sensitive in vivo methods on state-of-the art PET, SPECT, IR Fluorescence, Ultrasound, and other imaging systems.
-Very wide range of animal models from neuroscience to tumor research
-Two decades of experience in radiolabeling and measuring theranostics, nanoparticles and cells in living animal models
-Uniquely wide set of instruments from fluorescent microscopy through every major whole-body high resolution imaging modality (PET-SPECT-MRI-CT-US-Optical-Cerenkov)
-Femtomolar sensitivity and high throughput PET and SPECT systems
-Longitudinal imaging across time with single animals: reduction of animal numbers per study
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 739593. HCEMM supported by EU Programme: H2020-EU.4.a. – Teaming of excellent research institutions and low performing RDI regions. Project starting date was 1 April 2017.
